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Allogeneic Transplantation and Immunotherapy: From Bench to Bedside

Vak
2013-2014

Admission requirements

  • Successful completion of How To Write A Research Proposal not obligatory, but strongly recommended.

Description

Period: 2014-2015

The course will give insight into various clinical and research aspects of allogeneic hematopoietic stem cell transplantation and the use of allo-reactive T cells for treatment of hematological malignancies. Students will be introduced into these different aspects by seminars given by experts in the field followed by self-study assignments and a selection of recently published publications which will be presented and discussed in work-groups. During the course, students will practice in oral presentations on topics of their self-study assignment. Students will also visit the clinical department and the diagnostic and research laboratories of the Department of Hematology.

Students will be introduced into the following aspects of allogeneic hematopoietic stem cell transplantation:

  • Different hematological diseases, as well as treatment modalities and monitoring of hematological malignancies.

  • Allo-immunity; beneficial anti-tumor reactivity and undesired complications of allo-reactivity.

  • Allo-reactive T-cells; characterization of allo-reactive T-cells and their HLA-binding targets.

  • Interactions between leukemic cells and the immune system, donor selection and graft versus host disease.

  • Antibodies in alloSCT, and the use of therapeutic antibodies for treatment of hematological malignancies.

  • Clinical application and development of anti-tumor therapies; in vitro selection/generation of antigen specific T cells, TCR gene transfer.

This course will particularly work on:

Research competences:
defining a research question, study-design, choice of appropriate techniques, integration of different biomedical disciplines, knowledge of literature and methods, interpretation of results.

Professional competences:
team-work; participation in discussions; use of language; clarity, consistency and transparency in presentations; knowledge of literature and application of this knowledge, developing creativity by combining different perspectives.

Course objectives

To get detailed insight into the clinical and research aspects of:

  • allogeneic stem cell transplantation as treatment for hematological malignancies

  • allo-reactive T cells for treatment of hematological malignancies after allogeneic stem cell transplantation.

Mode of instruction

Plenary sessions, self-study assignments, work-groups

Assessment method

Assessment will be based on the quality of oral presentations and participations in discussions during the work-groups, written reports, and a final exam.